The reason consumers prefer different cannabidiol (CBD) products are due to the difference in their onset time. This is determined by the bioavailability and it is the amount of cannabidiol available in the bloodstream. The method of consumption, as well as the type of extract, used influences it. This also impacts its cost and effectiveness, the product is better if it has higher bioavailability. There are multiple factors that affect this and the purpose of this article is to better understand this, read on to know more.
As mentioned in the introduction, bioavailability is the amount of CBD available in the bloodstream after you consume any cannabidiol-infused product. It depends on multiple factors, like consuming CBD oil after a meal increases its bioavailability if the food is rich in fats. This is because natural CBD is oil or fat-soluble. But, this is mainly determined by the method of consumption and this depends on the reason why you are using that particular cannabidiol product.
CBD Bioavailability Of Different Products
The bioavailability varies for different CBD products like oils, tinctures, edibles, vapes, pills, and capsules.
CBD Bioavailability Of Oral Consumption
When you consume CBD orally in the form of edibles, drinks, pills, or capsules, first it has to pass through the digestive system before being absorbed into the bloodstream. This results in a loss of the part of cannabidiol consumed due to filtration from gut lining resulting in the lowest bioavailability i.e. 13% to 19%. This is very low compared to other methods of consumption but can be slightly increased if you consume it on an empty stomach, but still, it will be low.
CBD Bioavailability Of Sublingual Consumption
CBD tinctures and sprays are consumed sublingually and it has a slightly higher bioavailability of 20% to 30%. Here, cannabidiol enters the bloodstream directly through the tiny blood vessels under the tongue. Also, there is the added advantage of bypassing the liver’s first-pass metabolism increasing its bioavailability. This is because the loss in concentration is less due to the skipping of metabolic activity by liver enzyme CYP450. To ensure maximum absorption, you must hold it under your tongue for 20 to 60 seconds.
CBD Bioavailability Of Topical Application
The bioavailability of CBD topical products is fairly low compared to other methods because cannabidiol does not enter the bloodstream. However, their effect is fairly quick and localized because cannabidiol interacts directly with the cannabinoid receptors of ECS on the skin surface.
CBD Bioavailability Of Inhalation
The bioavailability of CBD vape products is the highest at around 60% because cannabidiol enters the bloodstream directly through the highly permeable surface of the lungs. Hence, it has the fastest onset time and the most effective method to consume CBD.
So, before using any cannabidiol (CBD) product know about its bioavailability to ensure that it is suitable for your ailment.